ChiroBlock provides customized compounds to the scientific community – we are pleased to present the recent publications from our customers!

Many of ChiroBlocks custom synthesis project are executed under a strict NDA. But we also keep a close eye on those that lead to publications in scientific journals. In this context we are proud to be the often chosen supplier and facilitator for various research entities such as universities, research institutions or innovative companies around the globe.
Of course we are particularly pleased about all the published research results to which we have been able to contribute. They range from medicinal basic research, microbiology and anti-cancer to APIs; from analytics to environmental research and environmental analytic to basic synthesis development.
Have a look yourself and see which specific research topics ChiroBlock has facilitated with the supply of custom synthesized substances. This builds an inspirational collection of exciting research publications.
Now 2024 is already coming to its closing chapter and we are looking forward to the hopefully positive outcomes of all our customers’ current projects.

Medicinal basic research:

• Sex, age, body mass index, and contraceptive use but not perceived stress influence healthy plasma lipidomic profiles
  Lisa Hahnefeld, Juliane Hackel, Sandra Trautmann, Carlo Angioni, Yannick Schreiber, Robert Gurke, Dominique Thomas, Sabine Wicker, Gerd Geisslinger, Irmgard Tegeder https://doi.org/10.21203/rs.3.rs-4408378/v1
• Optimierung der Chlorid-Kanalfunktion von mutantem Bestrophin-1
  Huttner, L.; Dissertation Uni Regensburg; https://doi.org/10.5283/epub.58290 / https://epub.uni-regensburg.de/58290/

Microbiology:

• Activation of neurokinin-III receptors modulates human atrial TASK-1 currents
  Felix Wiedmann, Amelie Paasche, Jendrik Nietfeld, Manuel Kraft, Journal of molecular and cellular cardiology, Volume 184, p. 26-36, November 2023
  https://doi.org/10.1016/j.yjmcc.2023.09.010
• Investigation of encapsulated water wire within self-assembled hydrophilic nanochannels, in a modified γ4-amino acid crystals: Tracking thermally induced changes of intermolecular interactions within a crystalline hydrate
  Krishnayan Basuroy,Jose de Jesus Velazquez-Garcia, Simone Techert, Amino Acids (2024) 56:9; https://doi.org/10.1007/s00726-023-03372-4

Anti-cancer:

• Hypoxia induced deregulation of sphingolipids in colon cancer is a prognostic marker for patient outcome
  El Hindi, K., Brachtendorf, S., Hartel, J. C., Renné, C., Birod, K., Schilling, K., … & Grösch,
  S. BBA-Molecular Basis of Disease, 1870 (2024), 166906 https://doi.org/10.1016/j.bbadis.2023.166906

Active pharmaceutical ingredients:

• Identification and structural elucidation of an oxidation product generated during stability studies of Cabergoline drug product
  Tilman Lechel, Ruben Silva Otero, Andreas Springer, Anja Rutkowski, Dominik Matzkow, Johannes Zart, Tobias Hartmann, Dieter Hochhuth
  Journal of Pharmaceutical and Biomedical Analysis, Volume 248, 15 September 2024, 116282; https://doi.org/10.1016/j.jpba.2024.116282

Analytics:

• Identification, Stability Studies and Structural Elucidation of an Oxidative Degradant of Cabergoline Drug Substance
  Tilman Lechel, Ruben Silva Otero, Andreas Springer, Anja Rutkowski, Dominik Matzkow, Johannes Zart, Tobias Hartmann, Dieter Hochhuth; Journal of Pharmaceutical and Biomedical Analysis, Volume 248, 15 September 2024, 116282, https://doi.org/10.1016/j.jpba.2024.116282
• All-in-one stability indicating polysorbate 20 degradation root-cause analytics via UPLC-QDa
  Stefan Carle, Dirk-H. Evers, Elina Hagelskamp, Patrick Garidel, Julia Buske; Journal of Chromatography B 1232 (2024) 123955; https://doi.org/10.1016/j.jchromb.2023.123955

Environmental research / environmental analytics:

• Exposure of young German adults to the anti-dandruff agent climbazole from 2002 to 2022: Analysis of specific biomarkers in urinary samples
  Isabell Schönrath, Christoph Schmidtkunz, Katja Küpper, Till Weber, Gabriele Leng, Marike Kolossa-Gehring; Chemosphere, Volume 367, November 2024, 143611 https://doi.org/10.1016/j.chemosphere.2024.143611
• A specific and sensitive GC–MS-MS method for the quantitative determination of 2-phenoxyethanol and selected metabolites in human blood and urine
  Jäger, T; Eckert, E.; Leibold, E.; Bader, M.; Journal of Analytical Toxicology, Volume 48, Issue 6, July 2024, Pages 419–428, https://doi.org/10.1093/jat/bkae037
• First evidence of widespread anticoagulant rodenticide exposure of the Eurasian otter (Lutra lutra) in Germany
  Julia Regnery, Simon Rohner, Julia Bachtin, Christel Möhlenkamp, Olaf Zinke,Stefanie Jacob, Peter Wohlsein, Ursula Siebert, Georg Reifferscheid, Anton FriesenScience of the Total Environment 907 (2024) 167938, https://doi.org/10.1016/j.scitotenv.2023.167938

Synthesis development:

• Design and Synthesis of Red-Absorbing Fluoran Leuco Dyes Supported by Computational Screening
  Deichmann, V.; Chercka, D.; Danner, D.; Rosselli, S.; Nelles, G.; Roberts, A.; Rodin, V.
  ACS Omega 2024, 9, 32, 34567–34576; https://doi.org/10.1021/acsomega.4c02646
• Nonengineered Fungus Provides a Shortcut from Cellulose to Bulk Erythro-isocitric Acid
  Schlembach, I.; Bardl,B.; Regestein, R.; Rosenbaum, M.; ACS Sustainable Chem. Eng. 2024, 12, 9, 3408–3418; https://doi.org/10.1021/acssuschemeng.3c04664